TABLE OF CONTENTS
All substances have some effect on the brain, and when an individual uses an illicit substance like heroin or cocaine, it changes how the brain processes and receives signals from the rest of the body. Heroin, for example, stimulates the brain and unnaturally activates neurons. Cocaine, on the other hand, interferes with the brain’s normal processes and makes certain neuron signals stronger. In both cases, the result is the high experienced from taking the substance.
Medications used for substance abuse treatment are intended to interfere with and ultimately counteract the damaging effects of illicit substances on the brain of the addict. These medications are prescribed to block illicit substances from being able to disrupt the brain’s normal processes or activate neurons in the usual way, which means the individual doesn’t experience the high from the substance and, thus, fall further into a cycle of abuse and addiction.
While it may seem strange at first to learn that a pill can combat alcohol addiction, the FDA has approved several medications for precisely this purpose. These medications usually work either by reducing cravings for alcohol or by making an individual sick if he or she does decide to drink. Additionally, some medications can help with physical withdrawal symptoms, which may make it easier to remain sober, particularly in the first few weeks or months. You can find out more about these medications, as well as other aspects of substance abuse treatment for alcohol addiction, in our Guide to Alcohol Rehab and Recovery.
Acamprosate works by dampening the positive effect that alcohol has on the brain, thus limiting the high an individual experiences from imbibing. It can also help ease the cravings that occur during withdrawal. In one study, subjects who took acamprosate were more likely to have maintained their sobriety after a year than those who were given a placebo. Other studies have revealed conflicting results, however, and the research into this medication for alcohol addiction is still ongoing.
Disulfiram works by making it more difficult for the body to break down and digest alcohol. This means that if an individual does drink, he or she will experience negative physical symptoms, including nausea, vomiting, heart palpitations, and a feeling of being overheated. A 2011 study published in the journal Alcoholism, Clinical and Experimental Research revealed that disulfiram use had a positive correlation with higher success rates for short-term sobriety, as individuals who took the medication had longer times between relapses and fewer drinking days than study participants using other treatment methods or taking a placebo.
Vivitrol is an injectable form of naltrexone. This extended-release medication works by blocking the brain from being able to receive the positive sensations that occur when an individual ingests alcohol or another illicit substance. Vivitrol has been shown to be effective in clinical studies, decreasing cravings and increasing one-year sobriety rates.
Medication for cocaine addiction treatment is used to combat the withdrawal symptoms that occur during the detoxification phase. These medications can help lessen the severity of common withdrawal symptoms such as depression, anxiety, and insomnia, as well as reduce cravings. You can find out more about medication, as well as other aspects of substance abuse treatment for cocaine addiction, in our Guide to Cocaine Rehab and Recovery.
Modafinil was originally developed to treat narcolepsy, but it was then discovered to show promise in aiding cocaine addiction treatment. However, studies to determine effectiveness as a treatment medication have had mixed results, and outside variables were found to be a large factor in its success. Modafinil has had the best results when combined with other treatments, such as behavioral therapy.
Medications used to manage opioid addiction differ from those used in cocaine and alcohol addiction treatment because some of them, such as methadone, can be addictive in and of themselves if not properly managed. These treatment medications block the high an individual receives from opioid use, which reduces positive reinforcement and eventually the desire to use the substance. You can find out more about these medications, as well as other aspects of substance abuse treatment for opioid addiction, in our Guide to Heroin Rehab and Recovery.
According to studies, buprenorphine has shown promise in its role in helping patients achieve long-term recovery. It’s available in both pill and implant form.
Studies reveal that methadone has been used successfully for years to help treat opioid addiction. It is generally considered effective, but there is some controversy surrounding this treatment because it can be addictive in and of itself if not appropriately managed.
Naltrexone has been shown to be effective in treating alcohol addiction, and, as mentioned earlier, its extended-release form, Vivitrol, can help patients better comply with opioid addiction treatment protocols.
According to studies, naloxone is extremely useful in treating opioid overdoses, and it has become an essential medication for hospitals and first responders, most commonly known as the brand names Narcan and Evzio. For long-term opioid addiction treatment, it is often combined with buprenorphine.
When a medication is first developed and utilized in clinical trials, it’s not uncommon for other possible applications to be discovered. This usually occurs when trial participants report side effects not initially known to be associated with the medication. Once enough participants experience the side effects to demonstrate a direct correlation to a medication, researchers can conduct specific studies to see if it may be helpful in other circumstances, such as substance abuse treatment. Following are several medications currently being used or investigated for use in substance abuse treatment.
Originally developed as a muscle relaxant for patients suffering from epilepsy, baclofen helps regulate dopamine levels, which can help stabilize moods and lessen drug cravings. A 2003 study found that baclofen was effective as part of opioid addiction maintenance treatment, but research is ongoing.
Bupropion is well-known for its use in treating depression and other mood disorders, as well as a medication for smoking cessation; however, it’s also being used off-label to help manage both cocaine and methamphetamine addiction.
Gabapentin was first developed as an anti-convulsant but has been used to manage withdrawal symptoms during methadone-assisted detoxification. A 2013 study found that patients who took gabapentin along with methadone required lower doses of methadone and had fewer withdrawal symptoms.
Mirtazapine was originally approved by the FDA in 1996 to treat depression but has been used off-label since then for a variety of conditions, from insomnia and sleep apnea to post-traumatic stress and obsessive-compulsive disorders. Initial studies have shown that mirtazapine has promise when used to treat alcohol addiction, especially in individuals whose addiction involves self-medication for depression and anxiety.
Topiramate had an original use as a prescription migraine treatment and as an anti-convulsant. However, a 2011 study published in BMC Psychiatry found that the medication had a marked positive effect on reducing alcohol cravings. It also alleviated early withdrawal symptoms and correlated to a better likelihood of the patient abstaining from drinking for at least the first 16 weeks of treatment.
Vigabatrin’s official use is as an anti-convulsant for individuals suffering from epilepsy, but it’s also been found to significantly reduce the addiction cravings associated with alcohol withdrawal, which can both increase the chances of a successful detoxification period and support ongoing sobriety. Consequently, it’s being investigated for use in treatment for alcohol addiction.
Substance abuse is a multifocal problem and, as such, it often requires a combination of treatment regimens to achieve success. The use of medications to lessen withdrawal symptoms, reduce drug cravings, and help patients handle some of the coping issues associated with the addiction is a welcome addition to the rehabilitation process. Combined with both individual and group behavioral therapies, these treatment medications may help addiction sufferers on their road to recovery.
Note: The purpose of this guide is to inform readers about the currently available and potential medications for substance abuse treatment and not to provide medical advice. Always consult with a physician or addiction treatment specialist before beginning a substance abuse treatment program.